![topcat software topcat software](https://media.arxiv-vanity.com/render-output/5459992/topcat-start.png)
![topcat software topcat software](http://svo2.cab.inta-csic.es/theory/vosa/help3/fotos/v5.0/results/topcat1.png)
#Topcat software update
The 2017 American College of Cardiology/American Heart Association focused update of the 2013 guidelines for the management of heart failure recommended a target systolic blood pressure (SBP) of <130 mm Hg in patients with HFpEF. 3, 4Īlthough hypertension treatment represents an important aspect of heart failure management, 5 a relative paucity of data exist on the management of this common comorbid condition in patients with HFpEF. 2 Systemic hypertension is the most prevalent modifiable risk factor, 1 and its presence confers an increased risk of developing clinically apparent heart failure. 1 HFpEF represents a complex clinical syndrome with multiple comorbidities, such as hypertension, diabetes mellitus, renal disease, metabolic syndrome, and atrial fibrillation. Heart failure with preserved ejection fraction (HFpEF) accounts for >50% of all heart failure cases, and this condition is increasing in frequency, along with associated morbidity, mortality, and healthcare costs. Multivariable Cox regression was used to examine the risk of hospitalization for heart failure, death, and cardiovascular death associated with DBP.
#Topcat software trial
This analysis included 1703 (mean age, 72☑0 years 50% men 78% white) patients with heart failure with preserved ejection fraction enrolled in the TOPCAT (Treatment of Preserved Cardiac Function Heart Failure With an Aldosterone Antagonist) Trial from the Americas who were treated for hypertension.